Table 1.

Examples of the Versatility of Functions of Cytoprotective Proteins

Conjugation and export

Glutathione transferases

UDP-glucuronosyltransferases

Multidrug resistance proteins

Glutathione homeostasis

γ-Glutamatecysteine ligase

Glutathione reductase

Thioredoxin

Thioredoxin reductase

Antioxidant

Heme oxygenase 1

Ferritin

Catalase

Antiinflammatory

Leukotriene B4 dehydrogenase

Synthesis of reducing equivalents:

Glucose-6-phosphate dehydrogenase

Maleate dehydrogenase

Repair and removal of damaged macromolecules

Heat shock protein 40

Heat shock protein 70

26S proteosome subunits

O6-methylguanine-DNA methyltransferase

UDP, uridine diphosphate.