Table 2.

One-pot, three-step synthesis of 1,4-disubstituted triazoles 3

entry	Ar-X	R	method Aa yield (%)	method Bb yield (%)
1	Ph-I	Bn	96	91
2	4-MeO-C6H4-I	Bn	41	54
3	4-CF3-C6H4-I	Bn	97	98
4	4-F-C6H4-I	Bn	98	98
5	4-Me-C6H4-I	Bn	93	95
6	2-Me-C6H4-I	Bn	97	98
7	Ph-Br	Bn	42	65
8	4-MeO-C6H4-Br	Bn	13	15(57c)
9	4-NO2-C6H4-Br	Bn	12	11(53c)
10	Ph-I	4-MeO-Bn\	84	91
11	Ph-I	4-NO2-Bn	97	98

^aA mixture of TBAF (1.0 M, 2.0 equiv) and CuI (10 mol %) was used

^bCuF₂ (2.0 equiv) was used

^cThe Sonogashira cross coupling was performed using Pd(PPh₃)₂Cl₂ (5 mol %), CuI (10 mol %) in refluxing Et₃N for 10 h.