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. Author manuscript; available in PMC: 2011 Nov 5.
Published in final edited form as: Org Lett. 2010 Nov 5;12(21):4876–4879. doi: 10.1021/ol102039c

Table 5.

Electrophile Compatibility

graphic file with name nihms241428u6.jpg
entry aryl electrophile % isolated yield
1 I 31
2 Br 85
3 OTf 93
4 OTs traces

All reactions were carried out using 0.3 mmol of 1a and aryl chloride, 2.5 mol % Pd(OAc)2, 5 mol %XPhos, 0.9 mmol of Cs2CO3, 10:1 CPME/H2O (0.09 M), 85 °C, 6 h.