Table 1. Summary of the clinical features of the three sample groups (normal unaffected, sporadic disease and FAP patients).
| Sample group | Sex (M/F) | Median age in years (range) | Total biopsy no. | Site of biopsy – right/left side of colon (ND) | Median size of adenoma in mm (range) | Pathology (TA/TVA) | Grade of dysplasia (low/high) |
|---|---|---|---|---|---|---|---|
| Normal | 6/1 | 60 (35–68) | 12 control | 1/11 | — | — | — |
| Unaffected | — | — | — | — | — | ||
| Sporadic | 12/10 | 65 (56–79) | 22 control | 0/22 | — | — | — |
| Disease | 22 adenoma | 1/21 | 10 (5–30) | 10/12 | 19/3 | ||
| FAP patients | 9/9 | 24 (18–38) | 18 control | 9/7 (6) | — | — | — |
| 30 adenoma | 9/15 (6) | 5 (2–35) | 29/1 | 29/1 |
Abbreviations: M=male; F=female; TA=tubular adenoma; ND=not documented; TVA=tubular villus adenoma.
Right-sided adenomas are taken between the rectum and splenic flexure, left-sided adenomas are from the transverse colon to the caecum.