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. 2010 Aug 10;103(6):877–884. doi: 10.1038/sj.bjc.6605811

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Copyright © 2010 Cancer Research UK

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miR-489 binds to the 3′ UTR of PTPN11 mRNA. A luciferase reporter assay used a vector encoding the partial PTPN11 3′ UTR (position 3300–3850). Renilla luciferase values are normalised against firefly luciferase values. Luciferase reporter assays were repeated using mutated vectors in which the candidate sites targeted by the miR-489 were deleted. ^*P<0.05