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. 2010 Nov;177(5):2268–2277. doi: 10.2353/ajpath.2010.100134

Figure 9.

Figure 9

A: SDF-1 induced up-regulation of Bcl-2 protein expression. R28 cells were serum-starved and cultured with rSDF-1 (100 ng/ml) for 24 hours, and total cell lysates were analyzed by Western blot. B: Quantification of the relative expression of Bcl-2. Results are representative of three independent experiments, expressed as the mean ± SEM. **P < 0.01. C: SDF-1 induced the phosphorylation of ERK. R28 cells were stimulated with rSDF-1 (100 ng/ml) for 5, 15, 30, or 60 minutes. D: Quantification of p-ERK/ERK ratio. Results are representative of three independent experiments, expressed as the mean ± SEM. **P < 0.01; versus control. E: ERK signaling was essential to the regulation of Bcl-2. After 3 hours of serum starvation, U0126 was applied 1 hour before SDF-1 treatment. F: Quantification of the relative expression of Bcl-2. **P < 0.01; versus dimethyl sulfoxide.