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. 2010 Nov;177(5):2278–2289. doi: 10.2353/ajpath.2010.100279

Figure 8.

Figure 8

Diagram of the pathogenesis of FECD. Endogenous and exogenous oxidative stress combined with genetic factors and postmitotic arrest of CE may lead to corneal edema seen in FECD since it causes oxidant-antioxidant imbalance, oxidative mitochondrial DNA damage, apoptosis, and CE morphological changes.