Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed scheme of the intracellular pathways involved in IL-1β–induced increase in intestinal epithelial tight junction (TJ) permeability. IL-1β treatment resulted in activation of the MEKK-1 and NIK signaling cascades. MEKK-1 activation resulted in a step-wise activation of IKK and the canonical NF-κB pathway and activation of the MLCK gene, culminating in the opening of the TJ barrier.
