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Representative IHC staining of MLH1 and PMS2 proteins. A and B: MLH1-expressing CRC and PMS2-expressing CRC, respectively, with their corresponding capillary-array-electrophoresis methylation-specific PCR results for MLH1 showing unmethylated signals only. C: CRC showing methylation of the MLH1 promoter region with corresponding absence of nuclear staining of MLH1, which is confirmed by underexpression of PMS2.
