Table 3.

Relation of Methylated Loci and MI to MLH1 Methylation Status and Protein Expression

No. of MINT loci methylated	No. of patients	MLH1		MLH1
		Average methylation index (SEM)	P*	IHC Nonexpressing† (%)	P*
0	32	0.14 (0.22)	0.007*	5 (16)	0.002*
1	7	0.08 (0.10)		2 (29)
2	4	0.01 (0.01)		1 (25)
3	5	0.72 (0.34)		1 (20)
4	2	0.42 (0.25)		2 (100)
5	4	0.43 (0.37)		4 (100)

^*Kruskal-Wallis test for correlation between methylated MINT loci and MLH1 MI or MLH1 protein expression. 

^†Confirmed by underexpression of PMS2.