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. 2010 Nov;177(5):2576–2584. doi: 10.2353/ajpath.2010.100466

Figure 2.

Figure 2

Neuroserpin-induced preconditioning in hippocampal neurons. A and B: Mean neuronal survival in hippocampal neurons cultured from wild-type mice and incubated either with neuroserpin 0 to 1 μmol/L (A) or tPA 60 nmol/L (B) 24 hours before exposure to lethal hypoxia (55 minutes of OGD); n = 20 for each observation. C and D: Mean neuronal survival in hippocampal neurons cultured from wild-type mice and incubated either with neuroserpin 0 to 1 μmol/L (C) or tPA 60 nmol/L (D) immediately before exposure to lethal hypoxia (55 minutes of OGD). Lines denote SD; n = 20 for each observation. Concentrations are given in nanomolar. Ns, Neuroserpin; PREC, preconditioning, denotes the moment when cells were treated with Ns or tPA.