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Effect of treatment with neuroserpin on the volume of the ischemic lesion. A: Volume of the ischemic lesion 24 hours after MCAO in Wt and tPA-deficient (tPA−/−) mice treated with neuroserpin (+) injected directly into the ischemic area; n = 12 per experimental group. Lines denote SD. B: Percentage decrease in the volume of the ischemic lesion in Wt and tPA−/− mice treated with neuroserpin immediately after MCAO; n = 12 per experimental group. Lines denoted SD.
