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. 2010 Nov;177(5):2597–2608. doi: 10.2353/ajpath.2010.100234

Figure 2.

Figure 2

Msh6−/− B-cell lymphomas display microsatellite instability. Differences in the size of the amplicon between normal tail DNA and tumor DNA from the same mouse, resolved on sequencing gels, indicate instability not encoded in the germline. A: Examples of instability at dinucleotide repeat D7Mit123 in tumors 624 and 981 and of mononucleotide repeat mBat37 in tumor 624 and of mononucleotide repeat A27 in tumor 599. B: Five Msh6−/− tumors, as well as a cell line derived from tumor 599, were stable at the (AAAAG)2 tract within the coding region of Tgfbr2. Stability was also observed at the (GT)3 repeat tract of the same gene (not shown).