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. 2010 Nov;177(5):2635–2644. doi: 10.2353/ajpath.2010.100177

Figure 1.

Figure 1

Lack of fetuin-A decreases mammary tumor incidence and increases tumor latency in PyMT/Fet−/− relative to PyMT/Fet+/+ and PyMT/Fet+/− mice. A: Kaplan-Meier survival curve showing that all of the PyMT/Fet+/+ and PyMT/Fet+/− mice in the study succumbed to mammary tumors by approximately 180 days of age, whereas more than 60% of the PyMT/Fet−/− mice were tumor-free at the end of the experiment at approximately 380 days of age. B: A typical genotyping assay revealed the 550-bp band of the PyMT oncogene. C: Mammary tissues from 60-day-old mice. Note that the acinus of PyMT/Fet−/− looks normal (arrow), whereas the acini of PyMT/Fet+/− and PyMT/Fet+/+ exhibit typical changes of multifocal intraepithelial neoplasia containing multifocal areas of glandular differentiation (arrows).