Table 3.
N | HR | 95% CI | P-Value | Overall P-Value | |||
---|---|---|---|---|---|---|---|
Female age | <35 | 162 | 1.00 | ref | ref | ||
35–39 | 156 | 0.78 | 0.58 | 1.03 | 0.08 | ||
≥ 40 | 89 | 0.29 | 0.18 | 0.45 | <0.001 | <0.001 | |
Male age | <35 | 126 | 1.00 | ref | ref | ||
35–39 | 129 | 0.70 | 0.51 | 0.97 | 0.03 | ||
≥40 | 101 | 0.56 | 0.39 | 0.81 | <0.001 | ||
Unknown | 52 | 0.53 | 0.33 | 0.84 | 0.01 | 0.004 | |
Prior children | No | 309 | 1.00 | ref | ref | ||
Yes | 97 | 1.10 | 0.81 | 1.50 | 0.53 | 0.53 | |
Prior pregnancy | 0 | 193 | 1.00 | ref | ref | ||
1 | 92 | 1.15 | .82 | 1.62 | .40 | ||
2 | 64 | 1.22 | .83 | 1.81 | .30 | ||
3+ | 40 | .81 | .49 | 1.32 | .39 | .41 | |
Prior fertility treatment | Oral medications | 251 | 1.05 | 0.79 | 1.40 | 0.74 | 0.74 |
Injectable medications | 94 | 1.26 | 0.92 | 1.71 | 0.15 | 0.15 | |
IUI | 139 | 1.04 | 0.79 | 1.40 | 0.74 | 0.74 | |
Duration of infertility | < 1 year | 69 | 1.00 | ref | ref | ||
1–2 years | 158 | 1.30 | 0.88 | 1.92 | 0.18 | ||
≥ 2 years | 152 | 0.89 | 0.59 | 1.33 | 0.56 | ||
Unknown | 29 | 0.69 | 0.35 | 1.37 | 0.29 | 0.03 | |
Couple fertility diagnosis | No known infertility factors | 18 | 1.00 | ref | ref | ||
Male factor only | 29 | 0.67 | 0.34 | 1.34 | 0.26 | ||
Female factor only | 238 | 0.45 | 0.26 | 0.78 | 0.01 | ||
Male and female factors | 123 | 0.36 | 0.20 | 0.64 | <0.001 | 0.002 | |
Female diagnosis | Tubal | 57 | 0.94 | 0.64 | 1.40 | 0.77 | 0.77 |
Uterine | 48 | 0.77 | 0.49 | 1.21 | 0.26 | 0.26 | |
Ovarian | 155 | 0.60 | 0.45 | 0.81 | <0.001 | <0.001 | |
Ovulatory | 109 | 1.29 | 0.96 | 1.73 | 0.09 | 0.09 | |
Any cycle-based treatment | No | 86 | 1.00 | ref | ref | ||
Yes | 322 | 2.28 | 1.51 | 3.43 | <0.001 | <0.001 | |
Medications only | No cycle based treatment | 86 | 1.00 | ref | ref | ||
1–2 cycles | 9 | 5.39 | 2.39 | 12.16 | <0.001 | ||
3+ cycles | 6 | 0.87 | 0.20 | 3.67 | 0.85 | <0.001 | |
Intrauterine insemination only | No cycle based treatment | 86 | 1.00 | ref | ref | ||
1 cycle | 33 | 3.14 | 1.81 | 5.44 | <0.001 | ||
2 cycles | 23 | 2.93 | 1.52 | 5.62 | <0.001 | ||
3 cycles | 15 | 3.12 | 1.53 | 6.34 | <0.001 | ||
4+ cycles | 20 | 1.63 | 0.79 | 3.39 | 0.19 | <0.001 | |
In vitro fertilization only | No cycle based treatment | 86 | 1.00 | ref | ref | ||
1 cycle | 83 | 2.46 | 1.52 | 3.98 | <0.001 | ||
2 cycles | 57 | 2.45 | 1.47 | 4.07 | 0.001 | ||
3+ cycles | 52 | 1.49 | 0.85 | 2.59 | 0.16 | <0.001 |