Table 1.
Endocannabinoids and N-acetylethanolamine levels in the hypothalamus, amygdala, caudate-putamen and prefrontal cortex of rats exposed to alcohol for 24 h and their corresponding controls
| HYPOTHALAMUS | AMYGDALA | |||
|---|---|---|---|---|
| Compound levels (pmol/g tissue) |
Control | Alcohol | Control | Alcohol |
| AEA | 30.06 ± 3.46 | 20.32 ± 2.46 * | 53.18 ± 5.13 | 32.83 ± 3.14 ** |
| 2-AG | 3311.7 ± 258.4 | 2659.1 ± 202.0 | 1935.8 ± 196.6 | 1744.5 ± 93.0 |
| LEA | 5.77 ± 0.98 | 4.40 ± 0.57 | 3.36 ± 0.60 | 6.09 ± 0.70 * |
| PEA | 290.6 ± 14.2 | 249.5 ± 13.7 | 132.9 ± 12.5 | 104.1 ± 7.1 |
| OEA | 341.4 ± 27.9 | 267.4 ± 15.3 * | 204.5 ± 25.6 | 164.9 ± 16.4 |
| SEA | 79.9 ± 5.1 | 65.1 ± 4.7 | 52.1 ± 2.6 | 37.2 ± 3.2 * |
| CAUDATE-PUTAMEN | PREFRONTAL CORTEX | |||
| Compound levels pmol/g tissue) |
Control | Alcohol | Control | Alcohol |
| AEA | 25.6 ± 2.1 | 19.8 ± 1.3 * | 16.7 ± 1.4 | 14.6 ± 0.6 |
| 2-AG | 1022.6 ± 98.4 | 974.9 ± 56.7 | 558.7 ± 31.8 | 413.0 ± 15.4 *** |
| LEA | 8.9 ± 3.1 | 5.2 ± 0.6 | 6.8 ± 1.2 | 5.1 ± 0.3 |
| PEA | 337.3 ± 10.9 | 293.8 ± 12.3 * | 144.6 ± 2.8 | 134.9 ± 5.7 |
| OEA | 386.9 ± 22.3 | 293.1 ± 13.6 ** | 240.9 ± 16.1 | 196.8 ± 9.2 * |
| SEA | 65.7 ± 4.4 | 58.4 ± 1.7 | 38.2 ± 3.1 | 36.7 ± 1.1 |
Data are means ± SEM of 8 animals in the alcohol group and 4 in the control group. Values were assessed by the two-way (brain region × alcohol treatment) analysis of variance followed by the Student-Newman-Keuls test (*p0.05, **p<0.01 and ***p<0.001 versus the control group).