Results of univariate analysis (pair-wise marginal protein-protein correlations). The positive correlation of CDK4/P27, CIAP2/SMAC and P53/RB as well as the inverse correlation found for BCL2/CDK4 corroborate our hypothesis that there seems to be an imbalance of apoptosis and proliferation/DNA damage control in CLL cells, when comparing genetically low-risk with high-risk cases.