Table 3.

Laboratory values in differential diagnosis of hypercalcemia.

	Serum calcium	Serum phosphorus	Fractional excretion of calcium	PTH	PTHrP	25(OH)D	1,25(OH)2D
Familial hypocalciuric hypercalcemia	↑	N or ↓	< 0.01	N or ↑	↓	N	↑
NSHPT	↑↑↑	↓	<0.01	↑↑	↓	N or ↓	↑
Subcutaneous fat necrosis	↑	↑	↑	↓	↓	N	↑↑
Williams syndrome	↑	↑	↑	↓	↓	N	N or ↑
Primary hyperparathyroidism	↑	↓	>0.01	↑	↓	N	↑
Humoral Malignancy	↑↑	↓	↑	↓	↑↑	N	N or ↑
Osteolytic malignancy	↑↑	↑	↑↑	↓	↓	N	↓
Granulomatous disease	↑	↑	↑↑	↓	↓	N	↑↑
Vitamin D intoxication	↑	↑	↑↑	↓	↓	↑↑	N or ↓
Immobilization	↑	↑	↑↑	↓	↓	N	↓