Table 1.

Exclusion criteria in ECASS III applied to the NINDS sample

	Placebo	t-PA
NINDS overall sample (n)	312	312
Excluded patients:
Age >80 years	29	40
Baseline NIHSS >25	23	29
Stroke involving >1/3 MCA	43	34
Known diabetic with prior stroke	25	26
Any heparin use	6	5
Final sample size (n)	199	200

Some patient were excluded for more than one reason