Table 2.
NINDS-ECASS III* Placebo | NINDS-ECASS III* t-PA | p | |
---|---|---|---|
n | 199 | 200 | |
Age (mean±SD) | 64.9 (10.8) | 66 (10.1) | 0.31 |
Gender (male) | 64.8% | 59.5% | 0.32 |
Treatment 0–90 min | 48.2% | 54% | 0.29 |
Treatment 90–180 min | 51.8% | 46.0% | |
Time to treatment (min) (mean±SD) | 118.6 (35.7) | 117.1 (37.9) | 0.69 |
NIHSS (mean±SD) | 13.8 (5.9) | 12.1 (6.0) | 0.0055 |
Blood pressure (mean±SD) | 113.5 (17.6) mmHg | 112.8 (17.7) mmHg | 0.73 |
Weight (kg) | 81 (18.9) | 76.6 (15.3) | 0.012 |
Current smoker | 36.0% | 38.9% | 0.63 |
Diabetes | 13.6 | 14.5 | 0.92 |
Prior stroke | 25.1 | 27.5 | 0.67 |
Hypertension | 64.5 | 63.8 | 0.98 |
Aspirin use | 28.6 | 40 | 0.022 |
Atrial fibrillation | 14.6 | 14.7 | 0.92 |
Patients from the NINDS sample fulfilling the ECASS III study criteria