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. 2010 Sep 7;103(8):1269–1276. doi: 10.1038/sj.bjc.6605880

Table 1. Summary of epigenetic patterns in normal and neoplastic testicular tissues.

  Putative function CIS Gonocytes a SEM NonSEM (EC) Normal adult testis
5-methyl-cytosine Chromatin repression neg neg neg/++ +++ Sp.gonia: all, Sp.cytes: all, Sp.tids: all
    Sertoli: ++ Sertoli: ++     Sertoli: ++
             
H3K9me2 Chromatin repression neg neg +/+++ neg Sp.gonia: A +++, Sp.cytes: neg, Sp.tids: round and elongated ++/neg
    Sertoli: +++ Sertoli: ++     Sertoli: neg/+
             
H3K27me3 Chromatin repression neg/+ neg/+ +++ neg Sp.gonia: neg/+, Sp.cytes: neg, Sp.tids: round to elongating +++/+
    Sertoli: +++ Sertoli: ++     Sertoli: +++
             
H3K4me1 Chromatin activation +++ neg/+ (cytoplasma) ++/+++ neg/+ Sp.gonia: B, Sp.cytes: neg, Sp.tids: late round ++
    Sertoli: + Sertoli: neg     Sertoli: +
             
H3K4me2/3 Chromatin activation ++/+++ −/++ neg/+ +/++ Sp.gonia: ++/+++, Sp.cytes: +/+++, Sp.tids: round +/++
    Sertoli: + Sertoli: −/+     Sertoli: +/++
             
H3K9ac Chromatin activation +++ +++ neg/+ neg/+ Sp.gonia: +++/+, Sp.cytes: ++/neg, Sp.tids: neg
    Sertoli: neg/+ Sertoli: neg/+     Sertoli: +
             
H2A.Z Chromatin activation +++ +++ ++/+++ neg/+ Sp.gonia: +/+++, Sp.cytes: ++, Sp.tids: round +++
    Sertoli: neg/+ Sertoli: neg/++     Sertoli: +
             
EZH2 H3K27 tri-methylation +++ (cytoplasma) Neg neg/+ neg Sp.gonia: neg (+ cytoplasma), Sp.cytes: neg, Sp.tids: neg
    Sertoli: neg Sertoli: neg     Sertoli: neg
             
UTX H3K27me3 demethylation neg Neg neg/+ neg/+ Sp.gonia: neg, Sp.cytes: neg/+, Sp.tids: neg
    Sertoli: + Sertoli: neg     Sertoli: neg
             
JMJD3 H3K27me3 demethylation neg neg/+ neg/+ neg/+ Sp.gonia: neg/+, Sp.cytes: neg/++, Sp.tids: neg/+
    Sertoli: neg/+ Sertoli: neg     Sertoli: neg/+ (cytoplasma)

Abbreviations: EC; embryonal carcinoma; EZH2, Enhancer of Zeste homologue 2; neg, negative; NonSEM, non-seminoma; SEM; seminoma; Sp.tid, spermatid; Sp.cytes, spermatocytes; Sp.gonia, spermatogonia.

+, faint staining; ++, apparent; +++, strong positive.

a

Gestational week 20–40.