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. 2010 Sep 14;103(8):1215–1220. doi: 10.1038/sj.bjc.6605895

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Copyright © 2010 Cancer Research UK

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miR-22 targets human HDAC4. (A) Sequence alignment of miR-22 and its conserved target site in HDAC4 3′ UTR (downloaded from TargetScan). (B) Luciferase expression of the indicated construct co-transfected with control RNA or miR-22 mimics. Data are shown as mean±s.d. (n=6). ^**P<0.01. (C) Hep3B and SMMC7721 cells were transfected as in Figure 4A. After 48 h, human HDAC4 and β-actin were detected by western blot.