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. 2010 Sep 14;103(8):1237–1244. doi: 10.1038/sj.bjc.6605897

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Copyright © 2010 Cancer Research UK

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Intracellular-delivered Id1/3-PA7 increases the expression level of CDKN2A. (A) Results of quantitative real-time PCR. Intracellular-delivered Id1/3-PA7 caused a dose-dependent increase in the relative mRNA level of CDKN2A compared with that in untreated or TrxA-treated (5 μg per 10⁶ cells) cells. The increased expression level of CDKN2A was counteracted by ectopically overexpressed Id1 and Id3. Bars: hatched, ES-2 cells; black, PA-1 cells. Results are represented as mean values of three independent experiments with s.d. (P⩽0.05). (B, C) Western blotting showed increased CDKN2A protein levels in Id1/3-PA7-treated (5 μg per 10⁶ cells) ES-2 and PA-1 cells, compared with that in untreated or TrxA-treated (5 μg per 10⁶ cells) cells.