Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Sep 14;103(8):1237–1244. doi: 10.1038/sj.bjc.6605897

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2010 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Id1/3-PA7 induces cycle arrest and apoptosis in ovarian cancer cells. (A–J) Quantification of cell-incorporated bromodeoxyuridine (BrdU) (fluorescein isothiocyanate (FITC) anti-BrdU) and total DNA content (7-AAD) in untreated and TrxA-treated (5 μg per 10⁶ cells) or Id1/3-PA7-treated (5 μg per 10⁶ cells) ES-2 cells (A, C) and PA-1 cells (D–F). Flow cytometric analysis of untreated cells vs Id1/3-PA7-treated cells showed S-phase reduction of actively cycling ES-2 cells (G) and PA-1 cells (I), increasing apoptotic cells in sub-G0/G1- and G2/M-resided ES-2 cells (H) and PA-1 cells (J). There were no significant differences between untreated and TrxA-treated cells (A–J). Bars: black, untreated; white dotted, TrxA treated; hatched, Id1/3-PA7 treated. Results are represented as mean values of three independent experiments with s.d. (P⩽0.05).