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. 2010 Sep 14;103(8):1237–1244. doi: 10.1038/sj.bjc.6605897

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Copyright © 2010 Cancer Research UK

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Apoptotic poly-ADP ribose polymerase (PARP) cleavage induced by Id1/3-PA7. (A, B) Untreated and TrxA- or Id1/3-PA7-treated (5 μg per 10⁶ cells) ES-2 and PA-1 cells were analysed for PARP cleavage by western blotting. PARP cleavage was detected in cell extracts of Id1/3-PA7-treated cells. (C, D) In Id1/3-PA7-treated cells, PARP cleavage was counteracted by ectopically overexpressed Id1 and Id3.