Table 2. Recurrent losses observed in the primary tumour and maintained through passages of the xenograft.
| Cytogenetic region | Start position* | End position* | Candidate genes |
|---|---|---|---|
| 1p34.3 | 34.4 | 34.9 | MIRN552 |
| 2q22.2 | 141.5 | 142.1 | Not known |
| 4p16.1–15.33 | 8.5 | 12.3 | GPR78, CPZ, DUB4, DEFB131, DRD5, SLC2A9, MIST, MIRN572, HS3ST1 |
| 4p15.2 | 25.1 | 26.5 | SLC34A2, RBPJ, CCKAR, TBC1D19, STIM2 |
| 4q35.1 | 186.8 | 189.0 | SORB2, TLR3, CYP4V2, KLKB1, F11, MTNR1A, MRPS36P2 |
| 7p22.2–7p22.1 | 3.1 | 5.9 | SDK1, FOXK1, RADIL, PAPOLB, MMD2, RBAK, WIPI2, SLC29A4, FBXL18, MIRN589, ACTB, EGID-654231 |
| 7p15.3 | 20.2 | 22.6 | ITGB8, ABCB5, SP8, SP4, DNAH11, CDCA7L, RAPGEF5, MGC87042 |
| 7p15.1 | 28.3 | 29.9 | CREB5, CPVL, CHN2, PRR15, WIPF3 |
| 30.1 | 31.1 | MIRN550-1, NOD1, GARS, CRHR2, INMT, AQP1, GHRHR, ADCYAP1R1 | |
| 7p14.3–14.1 | 32.5 | 43.0 | MIRN550-2, KBTBD2, FKBP9, NT5C3, RP9, BBS9, BMPER, AAA1, NPSR1, TBX20, MERPUD2, hCG1642425, SEPT7, ANLN, AOAH, ELM01, GPR141, TXNDC3, SFRP4, STARD3NL, T cell receptor gamma variable genes, AMPH, RALA, CDC2L5, INHBA, GLI3, TCP1L1, PSMA2, MRPL32 |
| 7p12.3 | 46.0 | 47.1 | EPS15L2 |
| 8p21.2 | 22.9 | 24.0 | TNFRSF10C, TNFRSF10D, TNFRSF10A, CHMP7, R3HCC1, LOXL2, ENTPD4, SLC25A37, NKX3.1, NKX2.6, STC1 |
| 25.2 | 25.5 | GNRH1, KCT9, CDCA2 | |
| 25.7 | 26.3 | EBF2, PPP2R2A, SDAD1P1 | |
| 8p21.1 | 27.4 | 28.6 | GULOP, CLU, SCARA3, CCDC25, PBK, PNOC, FBXO16, EXTL3 |
| 28.8 | 30.0 | KIF13B, DUSP4, MAP2K1P1 | |
| 31.9 | 32.1 | NRG1 | |
| 9p21.3 | 20.3 | 24.7 | MIRN491, PTPLAD2, IFNB1, IFNW1, IFNxxx…, LEIF-M, MIRN31, MTAP, CDKN2A, CDKN2B, DMRTA1, ELAVL2 |
| 9p21.2–21.1 | 27.3 | 28.9 | IFNK, LING02 |
| 10q22.1 | 72.1 | 74.2 | SGPL1, PCBD1, SLC29A3, CDH23, PSAP, CHST3, SPOCK2, ASCC1, SSIT4, DNAJB12, CBARA1 |
| 10q23.31 | 89.7 | 91.4 | LIPJ, LIPF, LIPK, LIPN, LIPM, ANKRD22, STAMBPL1, ACTA2, FAS, CH25H, IFIT2, LIPA |
| 10q23.33–24.1 | 96.5 | 98.6 | CYP2C19, CYP2C9, CYP2C8, PDLIM1, SORBS1, ALDH18A1, TCTN3, ENTPD1, CC2D2B, CCNJ, BLNK, DNTT, TMEM10, TLL2, TM9SF3, PIK3AP1, MIRN606 |
| 11q25 | 131.7 | 133.7 | OPCML, SPATA19, IGSF9B, JAM, PTP4AP2, NCAPD3, THYN1, ACAD8, GLB1L3 |
| 17p11.2 | 19.9 | 21.6 | SPECC1, COTL1P2, MEIS3P2, RNASEH1P1, HSP22, DHRS7B, TMEM11, MAP2K3, KCNJ12 |
| 18q21.2–21.33 | 46.9 | 61.0 | DCC, MBD2, POLI, STARD6, C18orf54, C18orf26, RAB27B, CCDC68, TCF4, AC009271.7, TXNL1, WDR7, AC100775.3, ST8SIA3, ONECUT2, FECH, NARS, ATP8B1, AC022724.8, AC090324.7, NEDD4L, ALPK2, AC104971.5, MALT1, AC104971.5, ZNF532, SEC11L3, GRP, RAX, CPLX4, LMAN1, CCBE1, PMAIP1, AC090377.15, MC4R, AC010928.7, CDH20, RNF152, PIGN, KIAA1468, TNFRSF11A, ZCCHC2, PHLPP, AC015989.11, BCL2, FVT1, VPS4B, SERPINB5, AC036176.8, SERPINB12, SERPINB13, SERPINB4, SERPINB3, SERPINB11, SERPINB7, SERPINB2, SERPINB10, SERPINB8 |
| 18q22.3 | 66.9 | 68.6 | CBLN2 |
| 68.8 | 72.8 | FBXO15, CYB5A, FAUP1, CNDP2, CNDP1 |
*
UCSC Genome Browser on Human May Assembly; positions are given in megabased.