Table 2. Relation of cytoplasmic Beclin 1 expression patterns to histopathological and hypoxia parameters.

	Cytoplasmic patterns
Parameter	Normal- like	Limited overexpression	Extensive overexpression	Underexpression	P-value
Stage
T3-N0	34	20	12	14	0.04a
T3-N1,2	28	16	21	10	—
Grade
1	26	12	4	8	<0.05b
2/3	36	24	29	16	—
Necrosis
No	22	6	14	12	<0.05c
Yes	40	30	19	12	—
Vascular invasion
No	50	26	20	16	0.03d
Yes	12	10	13	8	—
HIF1α
Low	26	6	7	12	<0.05e
High	36	30	26	12	—
LDH5
Low	20	12	2	8	<0.01f
High	42	24	31	16	—

^aExtensive vs all other.

^bExtensive vs each one of the other groups.

^cLimited vs each one of the other groups.

^dExtensive vs normal.

^eExtensive and limited overexpression vs each one of the rest.

^fExtensive overexpression vs each one of the rest.