Table 3. Influence of the chemotherapeutic initial dose on cytokines and complement components C3, C4, as well as the activation fragment C4d.

	Before initial dose			After initial dose			Paired Student's t-test
	Mean	s.d.	Units	Mean	s.d.	units	P-value
Cytokine panel
Discovery set (n=12)
TNFα	ND		pg ml−1	ND		pg ml−1	—
TNFβ	ND		pg ml−1	ND		pg ml−1	—
IFNγ	ND		pg ml−1	ND		pg ml−1	—
IL-1β	ND		pg ml−1	ND		pg ml−1	—
IL-2	27.7	29.4	pg ml−1	24.6	36.4	pg ml−1	0.491
IL-4	ND		pg ml−1	ND		pg ml−1	—
IL-5	ND		pg ml−1	ND		pg ml−1	—
IL-6	1.0	0.01	pg ml−1	4.5	1.6	pg ml−1	0.003
IL-8	2.6	17.6	pg ml−1	23.1	30.7	pg ml−1	0.268
IL-10	5.1	1.0	pg ml−1	8.5	3.5	pg ml−1	0.001
IL-12p70	ND		pg ml−1	ND		pg ml−1	—
sE-selectin	86.7	52.5	ng ml−1	88.8	55.5	ng ml−1	0.179
sICAM-1	453.5	177.4	ng ml−1	413.1	146.8	ng ml−1	0.181
sICAM-3	87.6	23.8	ng ml−1	64.1	20.7	ng ml−1	0.011
sPECAM-1	200.4	93.5	ng ml−1	139.4	61.7	ng ml−1	0.069
sP-selectin	428.5	182.5	ng ml−1	405	130.9	ng ml−1	0.178
sVCAM-1	420.8	622.4	ng ml−1	468.4	259.7	ng ml−1	0.288
Complement factors
Discovery set (n=12)
C3	144.2	15.40	mg per 100 ml	127.9	17.3	mg per 100 ml	0.002
C4	30.4	6.00	mg per 100 ml	24.5	6.8	mg per 100 ml	<0.001
C4d	3.6	1.40	μg ml−1	2.6	1.0	μg ml−1	0.007
Validation set (n=13)
C3	124.6	16.50	mg per 100 ml	118.1	19.3	mg per 100 ml	0.011
C4	27.0	5.90	mg per 100 ml	23.5	5.3	mg per 100 ml	0.019
C4d	2.8	1.00	μg ml−1	2.2	0.8	μg ml−1	0.004

Abbreviation: ND=not detectable.