A 48-year-old women with non-Hodgkin lymphoma. FDG-PET/CT axial images through the pelvis (a) before and (b) at 6 weeks after commencing chemotherapy. (a) A focus of bone marrow involvement (arrow) is noted in the left ilium, which shows moderately intense tracer uptake before treatment. (b) At 6 weeks after chemotherapy, there was complete absence of tracer uptake (arrow) in the affected left iliac bone in keeping with a complete metabolic response. Note area of increased sclerosis within the ilium (arrow) after treatment. (Courtesy of Dr Gary Cook, Royal Marsden Hospital, Sutton, UK.)