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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Stem Cells. 2010 Jul;28(7):1231–1242. doi: 10.1002/stem.449

Figure 4.

Figure 4

EphB3 regulates cell death in the SVZ of sham and CCI-injured mice. (A) Stereological counts of TUNEL-positive cells in the adult SVZ of wild type, ephrinB3−/− and EphB3−/− mice. The number of TUNEL-positive cells is reduced in the ipsilateral SVZ 3 days after CCI injury in wild type and ephrinB3−/−; but remains significantly lower in both sham- and CCI-injured EphB3−/− mice. Interestingly, there is greater cell death in the absence of eprhinB3 but reduced cell death in the absence of EphB3 compared to wild type in sham-injured animals. (B) Infusion of pre-clustered eB3-Fc can restore the level of cell death in ephrinB3−/− mice to wild type levels and significantly reduce the basal level of cell death in sham-injured wild type mice. The number of TUNEL-positive cells in the SVZ of EphB3−/− mice is unaffected by eB3-Fc infusion nor is there any effect in CCI-injured SVZ tissue. *P<0.05, ***P<0.001 compared to wild type sham; ###P<0.001 compared to ephrinB3−/− sham in panel A and *P<0.05 compared to corresponding Fc-control in panel B.