Fig. 3.

Typical case treated successfully. The patient received a kidney from his sister; both had type O blood. Fever, azotemia, hypertension, transplant wound tenderness, and proteinuria accompanied the relative oliguria and the decline in creatinine clearance which are depicted graphically. The changes were all reversed with the addition of prednisone and actinomycin C to the regimen. Leukopenia did not develop. Note the diminution of urine sodium concentration which is almost always observed during rejection and the paradoxical effect of prednisone in restoration of sodium excretion. Bilateral nephrectomy and splenectomy were performed at the same time as transplantation. Acti C: each arrow represents 200 gamma actinomycin C given intravenously.