Table I.

Maximum arterial changes in formed blood elements and in coagulation tests after the transplantation to sensitized recipients of 12 primary homografts (3 livers, 2 spleens, and 7 kidneys) and after the subsequent transplantation of 7 kidney homografts. By also repetitively analysing the venous effluent, the maximum arteriovenous (A–V) gradients were established across the various organs

	Platelet count (per mm.3)	Leucocyte count (per mm.3)	Fibrinogen (mg. %)	Factor* II (% normal)	Factor* V (% normal)	Factor* VIII (% normal)	Factor* IX (% normal)	Thrombin time (sec.)	Prothrombin time (sec.)	Partial thromboplastin time (sec.)	Euglobulin lysis time (min.)	Fibrin split products
Average maximum change in venous effluent compared to arterial blood†
Liver	−420,000	−8,577	−194	−47	−44	−70	−48	+40	+5.4	+9.3
Spleen	−190,000	−5,233	−110	−15	−8.5	−76	−31	+3.8	+4.1	+3.0
First kidney	−116,000	−4,536	−71	−10.5	−15	−19	−44	+3.3	+0.3	+1.7
Second kidney	−89,000	−5,325	−46	−9.5	−9.0	−15	−19	+4.5	+1.7	+2.2
Maximum changes in arterial blood†
Liver	−358,000	−9,011	−257	−61	−82	−76	−38	+7.5	+3.2	+14.2	−49	++
Spleen	−105,000	−2,996	−83	−20.5	−25.5	−31	−55	+1.4	+2.2	+3.5	−50	+
First kidney	−49,000	−1,735	−59	−12	−18.7	−27.5	−29.2	+2.3	+0.3	+2.8	−22	+
Second kidney	−76,000	−4,348	−34	−8.5	−10.1	−7	−16	+1.8	+1.4	+4.3	−16	+

^*Normal (100 percent) activity was defined as that present in canine plasma pooled from 8 healthy donors. The figures given are the mean changes in percentage activity.

^†The maximum arteriovenous gradients almost invariably developed within 1 to 5 minutes and then became progressively smaller with the passage of time. However, there were continuing changes in the systemic blood so that the maximum alterations in the aortic blood did not evolve until 20 to 40 minutes after the most extreme gradients.