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. Author manuscript; available in PMC: 2011 Oct 15.
Published in final edited form as: Circ Res. 2010 Aug 26;107(8):1002–1010. doi: 10.1161/CIRCRESAHA.110.217018

Figure 1. Reactive oxygen species increase tone in pressurized cerebral arteries.

Figure 1

A, Representative time course showing the luminal diameter of a pressurized (80 mm Hg) cerebral artery exposed to hypoxanthine (HX; 250 μmol/L) followed by xanthine oxidase (XO; 0.2mU/mL) plus HX. B, Plot of the mean ± SEM change in arterial tone (% Δ arterial tone) during HX and XO/HX exposure (n=7 arteries). C, Representative time course showing the luminal diameter of a pressurized (80 mm Hg) cerebral artery exposed to HX followed by XO/HX in the presence of the L-type Ca2+ channel blocker diltiazem (10 μmol/L). D, Plot of the mean ± SEM change in arterial tone (% Δ arterial tone) during diltiazem + HX and diltiazem + XO/HX exposure (n=3 arteries). *P<0.05