Fig. 3.

Impact of EH on estimating f_{m, CYPi}. A, when the f_{m, CYPi} of a victim drug is determined by intravenous administration of the drug in the presence and absence of potent inhibition, ignoring the EH of the victim drug affects the estimated f_{m, CYPi}, and the error in this parameter is a function of both EH and f_{m, CYPi}. B, the impact of this error is most apparent in the percent error in the maximum oral AUC ratio. This error is linear with respect to EH with a slope equal to −f_{m, CYPi} · 100 and therefore can be directly calculated as percent error = −f_{m, CYPi} · EH · 100.