Table 1.
Comparison of Sociodemographic and Psychiatric Characteristics of the Genetics of Alcoholism Sample and the Intact Families Sub-Sample, Before and After Data Weighting
| Genetics of Alcoholism Sample (%) | Intact Families Sub-Sample (%) | Odds ratios** | Weighted Intact Families Sub-Sample (%) | |
|---|---|---|---|---|
| Sociodemographics | ||||
| Cohort | ||||
| Females, under 35 | 23.25 | 4.61* | 1.0 | 18.04 |
| Females, 35–45 | 19.28 | 31.75* | 17.62 (11.65–26.65) | 22.99 |
| Females, over 45 | 25.19 | 31.50* | 52.45 (30.30–90.80) | 21.19 |
| Males, under 35 | 15.35 | 1.28* | 0.20 (0.09–0.44) | 17.77 |
| Males, 35–45 | 9.04 | 16.52* | 8.28 (4.66–14.70) | 11.56 |
| Males, over 45 | 7.90 | 14.34* | 39.54 (20.25–77.20) | 8.45 |
| Age (mean) | 43.59 | 45.53* | 0.92 (0.91–0.94) | |
| Pair gender | ||||
| Male – male | 17.83 | 24.84* | 2.54 (1.56–4.15) | 20.74 |
| Female – male | 25.76 | 21.77* | – | 27.61 |
| Female – female | 56.41 | 53.29* | 1.0 | 51.65* |
| Discordant pairs | ||||
| Family alcohol use history | ||||
| Twin | 11.18 | 12.29 | 0.77 (0.51–0.99) | 16.08* |
| Father | 10.70 | 11.27 | – | 18.89* |
| Mother | 2.92 | 2.94 | – | 2.30 |
| Spouse | 12.30 | 16.90* | – | 14.42 |
| Family depression history | ||||
| Twin | 27.88 | 35.98* | – | 31.30 |
| Father | 17.51 | 19.85 | – | 6.57* |
| Mother | 23.48 | 24.33 | – | 28.93* |
| Spouse | 20.59 | 29.83* | 1.33 (1.07–1.65) | 23.77 |
| Agoraphobia | 5.41 | 6.15 | 0.57 (0.35–0.93) | 5.99 |
| Panic | 1.64 | 2.69 | – | 1.39 |
| Social phobia | 3.20 | 4.87* | – | 3.37 |
| Other phobias | 2.72 | 4.10 | – | 2.88 |
| Abstain from alcohol | 3.37 | 3.33 | – | 3.04 |
| High-frequency drinking | 27.44 | 31.50 | – | 28.25 |
| High-density drinking | 19.71 | 20.23 | – | 21.31 |
| High maximum number of drinks | 20.51 | 17.67 | – | 17.10* |
| Migraine | 38.94 | 35.21 | – | 33.71* |
| Suicidal ideation | 3.81 | 6.53* | – | 6.57* |
| Major depression | 31.41 | 40.97* | 1.52 (1.22–1.90) | 35.39* |
| Alcohol dependence | 13.54 | 21.25* | 2.06 (1.55–2.74) | 18.26* |
| Conduct disorder | 8.53 | 13.44* | 1.79 (1.29–2.49) | 10.99* |
| Concordant pairs | ||||
| Family alcohol use history | ||||
| Twin | 1.16 | 2.69* | – | 3.78* |
| Father | 8.57 | 14.21* | – | 13.27* |
| Mother | 1.32 | 2.69* | – | 2.01 |
| Spouse | 0.84 | 1.54 | – | 0.76 |
| Family depression history | ||||
| Twin | 6.65 | 12.55* | – | 9.04* |
| Father | 5.57 | 8.19* | – | 0.39 |
| Mother | 8.89 | 16.39* | – | 9.83 |
| Spouse | 1.80 | 4.23* | – | 2.18 |
| Agoraphobia | 0.20 | 1.66* | – | 0.67 |
| Panic | 0.00 | 0.26* | – | 0.06 |
| Social phobia | 0.08 | 0.38 | – | 0.15 |
| Other phobias | 0.08 | 0.26 | – | 0.12 |
| Abstain from alcohol | 0.72 | 1.15 | – | 0.75 |
| High-frequency drinking | 10.34 | 14.21 | – | 15.05* |
| High-density drinking | 3.73 | 4.87 | – | 6.91* |
| High maximum number of drinks | 4.49 | 3.33 | – | 7.27* |
| Migraine | 19.79 | 32.52* | 1.47 (1.15–1.88) | 28.26* |
| Suicidal ideation | 0.16 | 0.77* | – | 0.39 |
| Major depression | 8.05 | 15.36* | 1.46 (1.02–2.09) | 12.15* |
| Alcohol dependence | 2.80 | 5.51* | 2.19 (1.23–3.91) | 6.34* |
| Conduct disorder | 1.44 | 3.20* | – | 2.58* |
Note. DZ =dizygotic; MZ =monozygotic.
*
Univariate comparisons with nonselected participants from the Genetics of Alcoholism Sample are significant, p<.05.
**
All listed odds ratios are significantly different from 1; p<.05. 95% confidence intervals are shown in parentheses. Nonsignificant odds ratios for remaining predictors are not shown.