Table 3.

Functional analysis of the 554 genes unique to large vessel atherosclerotic stroke when compared to controls (p <0.005, FC > |1.2|).

	LV	Genes	p-value
Canonical Pathways	Cytotoxic T lymphocyte target cell apoptosis	APAF1, CD247, FADD, FASLG, TRA@, TRD@	1.3×10−5
	CCR5 signaling in macrophages	CD247, FASLG, GNAI1, GNG*, MAPK13*, PRKCZ, TRA@, TRD@	1.3×10−4
	Relaxin signaling	GNAI1, GNG2, GUCY2D, MAPK1, MMP9, NF-κB IE, NPR2, PDE2A, PIK3R3, PRKACA, PRKCZ	1.5×10−4
	Corticotropin releasing hormone signaling	FASLG, GNAI1, GUCY2D, MAPK1, MAPK13, NPR2, NR4A1	1.0×10−3
	T lymphocyte regulation	CD247, NR4A1, PRKCZ, TRA@, TRD@, ZAP70*	1.3×10−3
Molecular Functions	T lymphocyte differentiation	ADA, TRA@, ZAP70	1.4×10−3
	Leukocyte development, morphology	ADA, APAF1, CCR8, CD83, CD247, CSF1, CSF2RA, CXCL12, EZH2, F5, FADD, FASLG, HIVEP2, IL12RB1, IL21R, ITGB7, MAPK1, NR4A1, PDIA3, PRKCZ, RAG1, RNASEL, SMAD7, THBS1, TRA@, XIAP, ZAP70	1.5×10−3
	Invasion of cells	MMP9, PLAUR	1.7×10−3
	Inflammatory disorder	ADA, ADORA3, ADRB2, ALOX5AP, APAF1, ARHGDIB, ARHGEF17, ASPH, ATP4B, C20ORF43, CA4, CA13, CAPN10, CD83, CD247, CDK6, CLCN6, COL9A3, COLQ, CORIN, CORO2A, CSF1, CSF2RA, CX3CR1, CXCL12, EGFL8, F5, FAM101B, FASLG, FBF1, GNG2, GRB10, HIC1, HIVEP1, HP, KIAA1908, LIMD1, LTB4R, MAPK13, MDC1, MMP9, MPHOSPH9, MSRA, MYH3, NFIA, NR4A1, NUMA1, OLAH, PACSIN2, PADI4, PCNX, PDE2A, PDIA3, PER1, PFTK1, PGLYRP1, PGM1, PHF19, PIK3R3, PITPNA, PLAUR, PMF1, PPARGC1B, PRKCZ, PRR5L, PTGDR, PXK, RAB7A, RAG1, RAPH1, RARG, ROPN1L, SAMSN1, SERPINE2, SEZ6L, SLC25A15, SLC26A8, SLC8A1, SLCO4C1, SPRED1, SPTLC2, SRPK2, STK36, TAF7L, TBC1D1, TGFBR3, THBS1, TKT, TNFSF8, TNIK, TRA@, TTC7A, TUBA4, TUBA4A, VARS2, ZEB1	2.8×10−3
	T cell development	ADA, APAF1, CCR8, CD83, CD247, CXCL12, F5, FADD, FASLG, HIVEP2, IL12RB1, IL21R, ITGB7, MAPK1, NR4A1, PDIA3, PRKCZ, RAG1, RNASEL, SMAD7, THBS1, TRA@, XIAP, ZAP70	5.2×10−3