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. 2010 Nov 1;5(11):e13788. doi: 10.1371/journal.pone.0013788

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Sanz-Arigita et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Intensities of SL values between any given pair of brain regions are color-coded (blue, SL = 0; red, SL = 1). Labels and guidelines represent groups of AAL brain ROIs. Upper left corner represents the synchronization level between brain regions in the right hemisphere; lower right corner is the synchronization within the left hemisphere; upper right corner (diagonal line) corresponds to the synchronization between hemispheres. On this region, main synchronization clusters are indicated: A) frontal cortex; A’) frontal cortex with pre and post-central gyri and parietal cortex; B) parietal and occipital cortices and precuneus; C) temporal lobe; C’) temporal lobe with parietal and occipital lobes. The overall synchronization pattern reveals a relative increase of connectivity in the frontal cortices in AD (A); compared to the control group (Figure 2), decreases of connectivity in AD are spread throughout temporal cortices (C and C’) and particularly the parietal and occipital region (B). Note that the synchronization matrices are symmetrical – lower half of the matrices are grayed out for convenience.