Table 1. Ortholog genes displaying lethality in knockout mouse models.

Prenatal/perinatal lethality	Postnatal lethality	Both pre- and postnatal lethality
PTCH1, STAT3, APOB, ANGPTL3, HIST1H1D, BCL11A, BMP4, JAK2, ALPL, GATA2, HBB, HHEX, LPL, SH2B1, CYP17A1, HNF1A, HNF4A, ATG16L1, ATP2B1, CDK6, CXCL12, KCNJ2, KIF1B, MAFB, SLC2A9, TNIP1, BRSK1, GNA12, HMGCR, NKX2-1, SOX17, TCF7L2, HNF1B, LMTK2	HFE, TNFRSF11B, LDLR, GLIS3, INS, TNFAIP3, FTO, NKX2-3, FOXE1, IKZF2, LEF1	FGFR2, ABCA1, BDNF, ERBB3, GCK, PTGER4, SMAD7, MAF