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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: J Neurochem. 2008 Sep 20;107(3):734–744. doi: 10.1111/j.1471-4159.2008.05644.x

Figure 1. Cell proliferation status in the brain and intestinal mucosa – in vivo BrdU incorporation.

Figure 1

Photomicrographs of immunohistochemical detection of BrdU incorporation into proliferating cell nuclei in the dentate gyrus hippocampal region and duodenal cross sections. A) Two hours after BrdU injection, positive nuclei are limited to the proliferative zone of duodenal crypts (brown). B) After a 48-hour incorporation period, BrdU positive cells accumulate and push upwards to replenish mucosal villi, reflective of the rapid turnover of mucosal cells. C) In contrast in the brain, BrdU administration over the 48-period resulted in limited incorporation; BrdU positive cells are indicated by arrows (dentate gyrus is a major site of neurogenesis). Insets show enlarged areas with BrdU positive cells (brown).