Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A schematic overview of the method. The TFA perturbations are estimated in an iterative fashion that trims unimportant edges from the regulatory (connectivity) network. If the data set is not NCA-compliant, additional data are generated in silico before estimating the TFA perturbations. Then, the significance of the TFA perturbations is assessed using the z-test and null distributions created by random sampling of expression data across the whole genome.
