Figure 3.

4-1BB/4-1BBL interactions during acute infection promote CD8 persistence. (A) WT (▪) and 4-1BBL^−/− (□) mice were infected with MCMV and numbers of virus-specific CD8⁺ cells were enumerated functionally 30 days later. (B and C) MCMV-infected WT mice were treated with IgG (▪) or α4-1BBL (□) antibody on days 0, 2 and 5 (B) or 7, 10 and 13 (C) and MCMV-specific CD8⁺ cells were enumerated functionally after 30 (B) or 28 (C) days. All results shown are mean numbers±SEM of four to six mice/group and representative of two independent experiments. ^*p<0.05, Student's t-test.