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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Gastroenterology. 2010 Aug 11;139(5):1567–1576.e6. doi: 10.1053/j.gastro.2010.07.057

Table 2.

Top SNPs from GWAS for primary and secondary end points

Trait SNP CHR POSITION Genes Minor MAF1 P12 Q-value1 β13 P24 Q-value2 β2
Primary end point
NAS rs2645424A 8 11721872 FDFT1 A 0.398 7.81E-07 1.05E-06 −0.76 6.75E-07 1.30E-06 −0.77
Secondary end points
Fibrosis rs343064R 7 35521313 - A 0.4 4.73E-08 4.26E-07 1.29 2.72E-08 2.45E-07 1.3
Lobular rs1227756R 10 71258510 COL13A1 G 0.461 1.14E-07 5.13E-07 0.58 2.01E-07 9.05E-07 0. 57
rs6591182R 11 65106332 LTBP3 A 0.467 6.69E-07 1.05E-06 0.54 8.66E-07 1.30E-06 0.54
rs887304A 12 3627809 EFCAB4B A 0.312 4.00E-07 1.05E-06 0.37 7.66E-07 1.30E-06 0.36
AST rs2499604D 1 236170124 ZP4 A 0.437 9.34E-07 1.05E-06 0.41 2.23E-06 2.51E-06 −0.38
rs6487679D 12 9262599 PZP G 0.164 8.74E-07 1.05E-06 0.41 1.26E-06 1.62E-06 0.39
rs1421201R 18 41226287 - G 0.492 7.34E-07 1.05E-06 0.44 1.09E-05 1.09E-05 0.39
rs2710833D 4 169646533 DDX60L PALLD A 0.168 2.35E-06 2.35E-06 0.39 6.27E-07 1.30E-06 0.41
1

Minor allele frequency;

3

β1 and β2 are the estimates of regression coefficient beta for the first and second covariate models, respectively;

2

P1 is the best p-value among three genetic models (additive, dominant, recessive) for the first covariate model: with age and BMI as covariates;

4

P2 is the best p-value among three genetic models for the 2nd covariate model: with age, BMI, diabetic status, waist-hip-ratio, and hba1c;

R

Recessive model;

A

Additive model;

D

Dominant model. Q-value1 is the Q-value corresponding to P1; Q-value2 is the Q-value corresponding to P2.