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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Curr Opin Plant Biol. 2010 Jul 16;13(5):548–555. doi: 10.1016/j.pbi.2010.06.002

Figure 2. Structural conservation and phylogenetic relationships within the eleven-member EPF gene family.

Figure 2

A. Protein sequence alignment of conserved C-termini generated using ClustalW2. The STOMAGEN propeptide is processed in vivo to yield the bioactive 45-amino-acid C-terminal fragment depicted above [18,19]. Among all EPFs, cysteine residues are strictly conserved at six positions. It was demonstrated with STOMAGEN that these residues form disulfide bridges and are essential for function [19]. B. A Neighbor-Joining phylogeny [36] of EPF family members generated using Kalignvu [37]. In contrast to CHALLAH and EPF1/2, which belong to distinct clades, STOMAGEN fails to cluster with any other EPF genes.