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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Semin Cell Dev Biol. 2010 Sep 19;21(8):845–854. doi: 10.1016/j.semcdb.2010.09.003

Table 1. Heterogeneity of SCs based on lineage history and muscle of origin.

SCs resident in different muscle groups originate from different embryonic tissues and can be discriminated according to their lineage history, based on Cre/loxP-mediated cell tracing experiments. Indicated Cre driver mice express Cre recombinase under the control of the regulatory sequences of specific genes and can be used for genetic labeling of precursor cells in vivo. A “+” indicates that SCs of the individual muscle are derived from, or induced to have been derived from (see notes), progenitors of the lineage that his mapped by the specific Cre driver.

Muscle group Developmental origin Lineage (Cre-drivers) References
Myf5Cre MyoDCre Pax3Cre MCre2 Mesp1Cre Isl1Cre
EOM Cranial unsegmented
mesoderm
+ + + [18-19, 127]
Branchiomeric Cranial unsegmented
mesoderm
+ +1 + + [18-19]
Tongue
(hypaxial)
Occipital somites + +1 + +1 + [19]
Limbs
(hypaxial)
Somitic
dermomyotome
+ + + + [18-19, 31,
87, 127]
Inter-limb
(hypaxial)
Somitic
dermomyotome
+1 + +3 +1 1 1 [127]
Back (epaxial) Somitic
dermomyotome
+1 +1 + 1 1 [30-31]
1

Not formally proven, but deduced from lineage studies on the corresponding muscle.

2

Hypaxial Pax3-enhancer [31].

3

Pax3nlacz/Pax3GFP are transcriptionally active in interlimb SCs (see text).

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