Table 1. Heterogeneity of SCs based on lineage history and muscle of origin.
SCs resident in different muscle groups originate from different embryonic tissues and can be discriminated according to their lineage history, based on Cre/loxP-mediated cell tracing experiments. Indicated Cre driver mice express Cre recombinase under the control of the regulatory sequences of specific genes and can be used for genetic labeling of precursor cells in vivo. A “+” indicates that SCs of the individual muscle are derived from, or induced to have been derived from (see notes), progenitors of the lineage that his mapped by the specific Cre driver.
| Muscle group | Developmental origin | Lineage (Cre-drivers) | References | |||||
|---|---|---|---|---|---|---|---|---|
| Myf5Cre | MyoDCre | Pax3Cre | MCre2 | Mesp1Cre | Isl1Cre | |||
| EOM | Cranial unsegmented mesoderm |
+ | + | − | − | + | − | [18-19, 127] |
| Branchiomeric | Cranial unsegmented mesoderm |
+ | +1 | − | − | + | + | [18-19] |
| Tongue (hypaxial) |
Occipital somites | + | +1 | + | +1 | + | − | [19] |
| Limbs (hypaxial) |
Somitic dermomyotome |
+ | + | + | + | − | − | [18-19, 31, 87, 127] |
| Inter-limb (hypaxial) |
Somitic dermomyotome |
+1 | + | +3 | +1 | − 1 | − 1 | [127] |
| Back (epaxial) | Somitic dermomyotome |
+1 | +1 | + | − | − 1 | − 1 | [30-31] |
1
Not formally proven, but deduced from lineage studies on the corresponding muscle.
2
Hypaxial Pax3-enhancer [31].
3
Pax3nlacz/Pax3GFP are transcriptionally active in interlimb SCs (see text).