Fig. 8.

The NF-κB pathway but not the Raf/MEK/ERK pathway is involved in cell invasion. Invasion of control, RKIP-knockdown and RKIP/MMP-1 and RKIP/MMP-2 double-knockdown T47D cells through Matrigel in the presence or absence of 10 µM U0126, a MEK inhibitor (A), or 10 µM DHMEQ, an NF-κB inhibitor (B), was evaluated. The values represent the means and SEM for the number of cells invading for six wells from three independent experiments. The experiments were conducted with the same cells and in the same manner as in Fig. 5B, with untreated cells assayed again in parallel with compound-treated cells.