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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Trends Endocrinol Metab. 2010 Sep 16;21(11):643–651. doi: 10.1016/j.tem.2010.08.002

Figure 2.

Figure 2

Figure 2

Figure 2

Determination of settling point for food intake. (a) Schematic of mechanisms that contribute to food intake, with those factors that exert pressure to decrease feeding listed on top, and those that tend to increase feeding listed on bottom. (c) Initial response to increased palatability/availability of food. This increases feeding by increasing the drive to eat. (c) New equilibrium for food intake in the continued presence of increased food palatability/availability. Increased feeding promotes increased adiposity, which increases leptin action to promote earlier satiation and additional effects to decrease feeding toward the initial baseline. With obesity, cellular mediators of leptin resistance are promoted in the hypothalamus, limiting leptin action and increasing the amount of leptin/adiposity required to suppress feeding.