Table 2.

Summary of lesions of long term survivors at euthanasia or death.

No rats.	Age range at death	LUNG	LIVER			PANCREAS	KIDNEY	TESTES
		(CIP)	Scaring	BDH&M	BD Cancer	Atrophy	(CIN)	Atrophy	Ca
Control rats for 3 and 8 weeks old groups. No CDE treatment
6	17.5–22.5	2*	0	0	0	0.3	2.5*	3*	5/6
3 weeks old rats, completed 5 cycles of CDE
8	12.5–17.5	2.2*	1	2.5	7/8	2.3	1.0*	2*	0
8 weeks old rat, completed 5 cycles of CDE
15	14–23.5	2.5*	0	1.1	1/15	1.2	1.9*	2.7*	0
Retired breeder controls, No CDE treatment
20	13–25	1.8*	0	0	0	0.4	1.5*	3*	11/20a
1 to 11/2 years old mice, completed 5 cycles of CDE
16	18–30	1.5*	0.2	0.3	0	0.7	3.7*	2.8*	11/14b

For grading of bile duct hypertrophy and metaplasia (BDH&M), lung, pancreas, kidney and testes lesions, see supplemental Figure 2.

^*Higher grades in older rats at time of death.

^aAll rats over the age of 18.5 months had an interstitial cell cancer of the testes

^bThere was no testes tissue on slides from two rats; two rats over the age of 20 months did not have interstitial cell carcinomas of the testes.

(Individual grading for each rat listed in Supplemental Table 2.).