Table 2.
No rats. | Age range at death | LUNG | LIVER | PANCREAS | KIDNEY | TESTES | |||
---|---|---|---|---|---|---|---|---|---|
(CIP) | Scaring | BDH&M | BD Cancer | Atrophy | (CIN) | Atrophy | Ca | ||
Control rats for 3 and 8 weeks old groups. No CDE treatment | |||||||||
6 | 17.5–22.5 | 2* | 0 | 0 | 0 | 0.3 | 2.5* | 3* | 5/6 |
3 weeks old rats, completed 5 cycles of CDE | |||||||||
8 | 12.5–17.5 | 2.2* | 1 | 2.5 | 7/8 | 2.3 | 1.0* | 2* | 0 |
8 weeks old rat, completed 5 cycles of CDE | |||||||||
15 | 14–23.5 | 2.5* | 0 | 1.1 | 1/15 | 1.2 | 1.9* | 2.7* | 0 |
Retired breeder controls, No CDE treatment | |||||||||
20 | 13–25 | 1.8* | 0 | 0 | 0 | 0.4 | 1.5* | 3* | 11/20a |
1 to 11/2 years old mice, completed 5 cycles of CDE | |||||||||
16 | 18–30 | 1.5* | 0.2 | 0.3 | 0 | 0.7 | 3.7* | 2.8* | 11/14b |
For grading of bile duct hypertrophy and metaplasia (BDH&M), lung, pancreas, kidney and testes lesions, see supplemental Figure 2.
Higher grades in older rats at time of death.
All rats over the age of 18.5 months had an interstitial cell cancer of the testes
There was no testes tissue on slides from two rats; two rats over the age of 20 months did not have interstitial cell carcinomas of the testes.
(Individual grading for each rat listed in Supplemental Table 2.).