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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Acta Biomater. 2010 Jul 30;7(1):123–132. doi: 10.1016/j.actbio.2010.07.033

Fig. 4.

Fig. 4

Proposed model describing macrophage activation on a-PEG-only, b-PEG-RGD and c-SIL materials. White dots represent biomaterial activation while black dots represent the combination of biomaterial activation and lipopolysaccharide stimulation over the culture period. Dots closer to the edge of the circle represent a more elevated responses in one of the three primary activation states and are indicative an activation phenotype. The dots represent the change in activation phenotype from the 4 hour time point to the 96 hour time point. Adapted by permission from Macmillan Publishing Ltd: Nature Reviews Immunology [12], copyright 2008.