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Morphology (a, b, d, e, g, h) and histological sections (c, f, i) of E10.5 mouse embryos derived from a Mrad9b+/− x Mrad9b+/− mating. All embryos are from the same litter. (a, c) and (b) Mrad9b+/+ embryos displaying normal gross morphology but of different size. (d) Mrad9b+/− embryo displaying normal gross morphology, (e, f) Mrad9b+/− embryo displaying a defect in neural tube closure. (g, i) Mrad9b−/− embryo growth arrested, (h) Mrad9b−/− embryo resorbed. NTD: neural tube defect.
