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. 2002 Sep 1;22(17):7434–7443. doi: 10.1523/JNEUROSCI.22-17-07434.2002

Fig. 1.

Fig. 1.

A, A KAR-mediated EPSP, recorded in the presence of GYKI 53655 and APV, was elicited in an interneuron recorded in area CA1 by stimulation in stratum radiatum (black trace). A lognormal fit to the EPSP is shown also (gray trace). B, A dual-component AMPAR- and KAR-mediated EPSP was elicited by stimulation (solid line). The late component of the EPSP was fit with a lognormal distribution (dotted line) to account for the KAR component of the EPSP. The inset shows the AMPAR EPSP isolated by subtraction of the lognormal distribution from the dual-component EPSP. C, The AMPAR-mediated EPSP shown in the inset of B is shown with a faster time base (black trace). A fit that uses the ADC distribution is shown also (gray trace).D, ADC and lognormal distributions with experimentally determined average parameter values were used to generate a model EPSP mediated by AMPARs (black trace) or KARs (gray trace). Scaling was determined by the relative sizes of the AMPAR and KAR components of the dual-component EPSPs. In this and all subsequent figures, all EPSPs that are shown are averages of 5–50 EPSPs. Calibration: A, 0.75 mV, 210 msec; B, 3.1 mV, 130 msec; C, 2 mV, 40 msec; D, 0.25 mV, 170 msec.